BACK

PD-L1 inhibition

CompoundDurvalumab

Area under investigation

Advanced solid tumors, BRCAm or PALB2m breast cancer, BTCs, Esophageal cancer, Gastric cancer, HCC, Metastatic urothelial carcinoma, Muscle-invasive bladder cancer, Non-muscle-invasive bladder cancer, NSCLC, RCC, SCLC, TNBC

Scientific PillarImmuno-Oncology

Target Overview

PD-L1 is a cell-surface protein that binds to the receptors PD-1 and CD80 on activated T cells, B cells, and other myeloid cells. PD-L1 binding to PD-1 on activated T cells has been found to interfere with T-cell proliferation and to inhibit immune responses.1 Overexpression of PD-L1 on cancer cells and solid tumors may allow these cells to avoid immune detection and elimination.2

Compound Overview

Durvalumab is an anti-PD-L1 mAb designed to bind PD-L1 and reduce the interaction between PD-L1 and its receptors. Durvalumab is being clinically evaluated in NSCLC, SCLC, UC, and various other solid tumors.

Mechanism of Action

  • Mechanism of Action
  • Mechanism of Action

Figures adapted from MedImmune Oncology Pipeline: Durvalumab, targeting PD-L1. ©2013 MedImmune, LLC. 11326A. AstraZeneca; 264701, May 2013.

References

1. Sznol M, Chen L. Clin Cancer Res. 2013;19(5):1021-1034.  2. Creelan BC. Cancer Control. 2014;21(1):80-89.

Clinical trial information


Select trial for more information

Arrange By

Abbreviations

View full glossary

  • 1L

    first line

  • 2L

    second line

  • 3L

    third line

  • aBTC

    Advanced Biliary Tract Cancer

  • ADA

    anti-drug antibody

  • AE

    adverse event

  • AESI

    adverse event of special interest

  • AJCC

    American Joint Committee on Cancer

  • AJCC v7

    American Joint Committee on Cancer version 7

  • ALK

    anaplastic lymphoma kinase

  • ALT

    alanine aminotransferase

  • anti-HBc

    anti–hepatitis B core antibody

  • AoV

    ampulla of Vater

  • APF12

    alive and progression free survival at 12 months

  • AST

    aspartate aminotransferase

  • BCC

    basal cell carcinoma

  • BCG

    Bacillus Calmette-Guérin (biologic)

  • BCLC

    Barcelona Clinic Liver Cancer

  • BICR

    blinded independent central review

  • BID

    twice daily

  • BOR

    best overall response

  • BRAF

    v-raf murine sarcoma viral oncogene homolog B1

  • BRCAm

    BRCA mutated

  • BTCs

    biliary tract cancers

  • CCA

    Cholangiocarcinoma

  • cCRT

    concurrent chemoradiation therapy

  • CD80

    cluster of differentiation 80

  • CIS

    carcinoma in situ

  • Cmax

    maximum observed plasma concentration of a drug

  • CNS

    central nervous system

  • CR

    complete response

  • CRR

    complete response rate

  • CRT

    chemoradiotherapy

  • cStage

    clinical stage

  • CT

    chemotherapy

  • cTACE

    conventional transarterial chemoembolization

  • CTCAE

    Common Terminology Criteria for Adverse Events

  • CTCAE v.5

    Common Terminology Criteria for Adverse Events version 5

  • Ctrough

    Lowest observed concentration of study drug before the next dose is administered

  • Ctrough

    Trough Plasma Concentration

  • CTLA-4

    cytotoxic T–lymphocyte-associated antigen 4

  • D

    durvalumab

  • Dato-DXd

    datopotamab deruxtecan

  • DCR

    disease control rate

  • dCRT

    definitive chemoradiation therapy

  • DDFS

    distant disease-free survival

  • DEB-TACE

    drug-eluting bead-TACE

  • DFS

    disease-free survival

  • DNA

    deoxyribonucleic acid

  • DoR

    duration of response

  • DoT

    duration of treatment

  • EBV

    Epstein-Barr virus

  • eCCA

    extrahepatic cholangiocarcinoma

  • ECOG

    Eastern Cooperative Oncology Group

  • ECOG PS

    Eastern Cooperative Oncology Group Performance Score

  • EFS

    event-free survival

  • EGFR

    epidermal growth factor receptor

  • EGFRm

    epidermal growth factor receptor mutation

  • EORTC

    European Organization for Research and Treatment of Cancer

  • EORTC QLQ-C30

    European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire

  • EORTC QLQ-NMIBC24

    European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Non-Muscle-Invasive Bladder Cancer 24

  • EP

    carboplatin or cisplatin + etoposide

  • EQ-5D-5L

    EuroQol-5 Dimensions-5 Levels

  • ES-SCLC

    extensive stage small-cell lung cancer

  • ESCC

    esophageal squamous cell carcinoma

  • EV

    enfortumab vedotin

  • FACT-BL

    functional assessment of cancer therapy-bladder

  • FH

    fumarate hydratase

  • FIGO

    International Federation of Gynecology and Obstetrics

  • FKSI

    Functional Assessment of Cancer Therapy-Kidney Symptom Index

  • FLOT

    fluorouracil, leucovorin, oxaliplatin and docetaxel

  • GBC

    gallbladder cancer

  • GEJ

    gastroesophageal junction

  • Gem-Cis

    gemcitabine and cisplatin

  • GI

    gastrointestinal

  • GHS

    global health status

  • HBcAb

    hepatitis B core antibody

  • HBsAg

    HBV surface antigen

  • HBV

    hepatitis B virus

  • HCC

    hepatocellular carcinoma

  • HCV

    hepatitis C virus

  • HDV

    hepatitis D virus

  • HIV

    human immunodeficiency virus

  • HNSCC

    head and neck squamous cell carcinoma

  • HRQoL

    health-related quality of life

  • I

    induction

  • IASLC

    International Association For The Study Of Lung Cancer

  • iCCA

    intrahepatic cholangiocarcinoma

  • ICR

    independent central review

  • ICT

    investigator's choice therapy

  • iDFS (IDFS)

    invasive disease-free survival

  • IHC

    immunohistochemistry

  • ILD

    interstitial lung disease

  • imAEs

    immune-mediated adverse events

  • IMP

    investigational medicinal product

  • IP

    investigational product

  • IRRs

    infusion-related reactions

  • ITT

    intention to treat

  • IV

    intravenous

  • IVES

    intravesical

  • KEAP1

    Kelch-like ECH-associated protein 1

  • KRAS

    Kirsten rat sarcoma viral oncogene homolog

  • LRT

    locoregional treatment

  • LS-SCLC

    limited-stage small cell lung cancer

  • M

    maintenance

  • M1

    distant metastasis-cancer has spread to other parts of the body

  • mAb

    monoclonal antibody

  • mCRPC

    metastatic castration-resistant prostate cancer

  • MET

    hepatocyte growth factor receptor

  • MHC

    major histocompatibility complex

  • MIBC

    muscle invasive bladder cancer

  • MOA

    mechanism of action

  • MPR

    major pathologic response

  • MRD+

    minimal residual disease positive

  • mRECIST

    modified Response Evaluation Criteria in Solid Tumors

  • MRI

    magnetic resonance imaging

  • MSS-CRC

    microsatellite stable-colorectal cancer

  • NEC

    large cell neuroendocrine carcinoma

  • NMIBC

    non-muscle-invasive bladder cancer

  • NSCLC

    non-small cell lung cancer

  • NTRK

    neurotrophic tyrosine receptor kinase

  • OC

    ovarian cancer

  • OD

    once daily

  • ORR

    overall or objective response rate

  • OS

    overall survival

  • OS-12

    overall survival at 12 months

  • OS-24

    overall survival at 24 months

  • OTRR

    objective tumor response rate

  • PALB2m

    partner and localizer of BRCA2 gene mutated

  • PCI

    prophylactic cranial irradiation

  • pCR

    pathological complete response

  • PD

    progressive disease

  • PD-1

    programmed cell death-1

  • PD-L1

    programmed cell death ligand-1

  • PD-L2

    programmed cell death ligand-2

  • PDC

    platinum doublet chemotherapy

  • PFS

    progression-free survival

  • PFS-12

    progression-free survival at 12 months

  • PFS-18

    progression-free survival at 18 months

  • PFS2

    time to second progression or death

  • PFS24

    PFS at 24 months from randomization

  • PK

    pharmacokinetics

  • PO

    per oral

  • PORT

    post-operative radiation therapy

  • PR

    partial response

  • PRAEs

    possibly related to treatment adverse events

  • pRCC

    papillary renal cell carcinoma

  • PRO

    patient-reported outcomes

  • PRO-CTCAE

    Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events

  • PS

    phosphatidylserine

  • PtCh

    platinum-based chemotherapy

  • PVT

    portal vein thrombosis

  • PVTT

    portal vein tumor thrombosis

  • Q*W

    every * weeks

  • Q28

    every 28

  • Q3W

    every 3 weeks

  • Q4W

    every 4 weeks

  • QD

    once daily

  • QLQ-BIL21

    21-item Cholangiocarcinoma and Gallbladder Cancer Quality of Life Questionnaire

  • QLQ-C30

    Quality of life Questionnaire-C30

  • QnW

    every n weeks

  • QoL

    quality of life

  • R

    randomization

  • RCC

    renal cell carcinoma

  • RECIST

    Response Evaluation Criteria in Solid Tumors

  • RECIST v1.1

    Response Evaluation Criteria in Solid Tumors version 1.1

  • RET

    rearranged during transfection

  • RFS

    recurrence-free survival

  • RFS2

    time from randomization to recurrence on next therapy

  • RFS24

    proportion of recurrence-free survival at 24 months

  • RFS36

    proportion of recurrence-free survival at 36 months

  • RNA

    ribonucleic acid

  • RT

    radiotherapy

  • SAE

    serious adverse event

  • SBRT

    stereotactic body radiation therapy

  • SCC

    squamous cell carcinoma

  • SCLC

    small cell lung cancer

  • SCRT

    short course radiation therapy

  • sCRT

    sequential chemoradiation therapy

  • SD

    stable disease

  • SLE

    systemic lupus erythematosus

  • SoC

    standard of care

  • STK11

    serine/threonine kinase 11

  • STRIDE

    Single Tremelimumab Regular Interval Durvalumab

  • T

    tremelimumab

  • TACE

    transarterial chemoembolization

  • TB

    tuberculosis

  • tBRCAm

    tumor BRCA mutated

  • TC

    tumor cell

  • TCC

    transitional cell carcinoma

  • TCR

    T-cell receptor

  • TDT

    time to discontinuation or death

  • TEAE

    treatment emergent adverse event

  • TFST

    time to first subsequent therapy

  • TIGIT

    T-cell immunoreceptor with immunoglobulin and ITIM domains

  • TMB

    tumor mutation burden

  • TNBC

    triple-negative breast cancer

  • TNM

    tumor node metastasis staging

  • TROP2

    trophoblast cell-surface antigen 2

  • tSCLC

    transformed small cell lung cancer

  • TSST

    time to start of second subsequent therapy

  • TTD

    time to deterioration

  • TTD

    time to treatment discontinuation

  • TTDM

    time to death or distant metastases

  • TTP

    time to progression

  • TTR

    time to recurrence

  • TURBT

    transurethral resection of bladder tumor

  • UC

    urothelial cancer

  • uHCC

    unresectable hepatocellular carcinoma

  • Vp1

    segmental portal vein

  • Vp3

    first-order branch of the portal vein

  • Vp4

    main trunk of the portal vein or contralateral first-order branch

  • WHO

    World Health Organization

Some compounds herein refer to selected AstraZeneca pipeline products still under development. AstraZeneca pipeline products are investigational products and, as such, are not approved by the US Food & Drug Administration (FDA), the European Medicines Agency (EMA) or any other regulatory agency for the uses under investigation. Information regarding these investigational products should, under no circumstances, be regarded as a recommendation for their use or of their safety or efficacy.

This site is intended for US Healthcare Professionals.

Veeva ID: Z4-80919 US-109129 DE-92568 Last Updated April 20263/26
©2026 AstraZeneca. All rights reserved.