DDR Overview

Compound Ceralasertib

Area under investigation

Advanced solid tumors, NSCLC, Ovarian cancer, TNBC

Scientific Pillar DNA Damage Response

Compound AZD9574

Area under investigation

Advanced solid tumors

Scientific Pillar DNA Damage Response

Compound Saruparib

Area under investigation

Advanced solid tumors, HR-positive/HER2-negative breast cancer, Localized prostate cancer, mCRPC, mHSPC, Ovarian cancer, Pancreatic cancer, TNBC, NSCLC, SCLC, BRCAm or PALB2m breast cancer

Scientific Pillar DNA Damage Response

Compound AZD9574

Area under investigation

Advanced solid tumors

Scientific Pillar DNA Damage Response

Compound AZD1390

Area under investigation

Primary glioblastoma multiforme and recurrent glioblastoma multiforme

Scientific Pillar DNA Damage Response

Compound Saruparib

Area under investigation

Advanced solid tumors, HR-positive/HER2-negative breast cancer, Localized prostate cancer, mCRPC, mHSPC, Ovarian cancer, Pancreatic cancer, TNBC, NSCLC, SCLC, BRCAm or PALB2m breast cancer

Scientific Pillar DNA Damage Response